DS-1205
DS-1205 is a highly potent and selective AXL kinase inhibitor (IC50 = 1.3 nM), with additional activity against MER, MET, and TRKA kinases. This small molecule has demonstrated efficacy in suppressing cell migration in vitro and impeding tumor growth in animal models, supporting its research use in oncology and metastasis studies.
Product Specifications
CAS Number
1855860-24-0
Product Name Alternative
C-Met/HGFR, DS 1205, DS1205, DS-1205, DS-1205b, AXL, Axl, Inhibitor, Mer, NIH3T3, MET, migration, kinase, inhibit, Tropomyosin related kinase receptor, TRKA, Trk Receptor, Tyro3, tumor, TAM Receptor, TAMReceptor
Field of Research
Signal Transduction
Purity
99.28% (May vary between batches)
Solubility
DMSO:45 mg/mL (61.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.72 mM)
Smiles
COc1cc (ccc1OC[C@H]1COCCO1) -c1cnc (N) c (c1) -c1ccc (NC (=O) c2cn (CC3CCOCC3) cc (-c3ccc (C) cn3) c2=O) cc1F
Molecular Formula
C41H42FN5O7
Molecular Weight
735.8
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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