Tolebrutinib
Tolebrutinib is a potent, selective, and brain-penetrant BTK inhibitor with IC50 values of 0.4 nM and 0.7 nM in Ramos B cells and HMC microglia cells, respectively. It is an orally active compound used in research for multiple sclerosis, demonstrating efficacy in models of central nervous system immunity.
Product Specifications
CAS Number
1971920-73-6
Product Name Alternative
Bruton tyrosine kinase, Bruton, BTK, Btk, inhibit, multiple, kinase, Inhibitor, PRN2246, PRN-2246, PRN 2246, SAR442168, SAR-442168, SAR 442168, sclerosis, Tolebrutinib, tyrosine
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.40% (May vary between batches)
Solubility
DMSO:100 mg/mL (219.53 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.78 mM)
Smiles
Nc1nccc2n ([C@@H]3CCCN (C3) C (=O) C=C) c (=O) n (-c3ccc (Oc4ccccc4) cc3) c12
Molecular Formula
C26H25N5O3
Molecular Weight
455.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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