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NRX-252262

NRX-252262 is a small molecule that potently enhances the interaction between β-catenin and the SCFβ-TrCP E3 ligase, leading to targeted degradation of mutant β-catenin with an EC50 of 3.8 nM. It serves as a valuable chemical probe for studying Wnt/β-catenin signaling in cancer research and has demonstrated proof-of-concept efficacy in cellular models of oncogenesis.

Product Specifications

CAS Number

2438637-61-5

Product Name Alternative

Beta catenin, betacatenin, beta-catenin, bcatenin, Inhibitor, inhibit, NRX252262, NRX-252262, NRX 252262, SCF (β-TrCP) -E3 ligase, Wnt/β-catenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, βcatenin, β-catenin

Field of Research

Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.94% (May vary between batches)

Solubility

DMSO:8 mg/mL (14.67 mM)

Smiles

COc1cc2CN (Cc2cc1OC) C (=O) c1c (Sc2c (Cl) cccc2Cl) cc ([nH]c1=O) C (F) (F) F

Molecular Formula

C23H17Cl2F3N2O4S

Molecular Weight

545.36

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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