NRX-252262
NRX-252262 is a small molecule that potently enhances the interaction between β-catenin and the SCFβ-TrCP E3 ligase, leading to targeted degradation of mutant β-catenin with an EC50 of 3.8 nM. It serves as a valuable chemical probe for studying Wnt/β-catenin signaling in cancer research and has demonstrated proof-of-concept efficacy in cellular models of oncogenesis.
Product Specifications
CAS Number
2438637-61-5
Product Name Alternative
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.94% (May vary between batches)
Solubility
DMSO:8 mg/mL (14.67 mM)
Smiles
COc1cc2CN (Cc2cc1OC) C (=O) c1c (Sc2c (Cl) cccc2Cl) cc ([nH]c1=O) C (F) (F) F
Molecular Formula
C23H17Cl2F3N2O4S
Molecular Weight
545.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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