Iptacopan hydrochloride
Iptacopan hydrochloride (LNP023 hydrochloride) is a potent, selective, and orally active inhibitor of human factor B, exhibiting high-affinity reversible binding with a KD of 7.9 nM and an IC50 of 10 nM. It is a valuable research tool for studying the alternative complement pathway in both in vitro assays and in vivo disease models.
Product Specifications
CAS Number
1646321-63-2
Product Name Alternative
Factor B, Inhibitor, hemolytic, hemoglobinuria, nocturnal, paroxysmal, pathogenesis, pathway, Iptacopan hydrochloride, Iptacopan Hydrochloride, Iptacopan HCl, Iptacopan, inhibit, LNP-023, LNP023 hydrochloride, LNP023 Hydrochloride, LNP-023 Hydrochloride, LNP 023, LNP 023 Hydrochloride, LNP023, alternative, atypical, Complement System, ComplementSystem, complement, system, syndrome, PNH, uremic
Field of Research
Immunology & Inflammation
Purity
97.03% (May vary between batches)
Solubility
DMSO:252 mg/mL (549.04 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.89 mM) ; H2O:50 mg/mL (108.94 mM)
Smiles
Cl.CCO[C@H]1CCN (Cc2c (OC) cc (C) c3[nH]ccc23) [C@@H] (C1) c1ccc (cc1) C (O) =O
Molecular Formula
C25H31ClN2O4
Molecular Weight
458.98
Storage Conditions
-20°C
Notes
For research use only.
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