NCGC00378430
NCGC00378430 is a small molecule inhibitor that potently disrupts the SIX1/EYA2 protein-protein interaction. This disruption impedes epithelial-mesenchymal transition (EMT) and metastatic progression, making it a valuable chemical probe for studying developmental biology, cancer metastasis, and tumor invasion in both cellular and animal models.
Product Specifications
CAS Number
920650-00-6
Product Name Alternative
P-Smad3, T47D, SIX1, SIX1-EYA2, Phosphatase, TGF-β, transcriptional, inhibit, Inhibitor, NCGC00378430, NCGC-00378430, NCGC 00378430, EYA2, FN1, EMT, E-CAD, MCF7, cancer, breast
Field of Research
Metabolism Research
Purity
99.74% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.47 mM) ; DMSO:90 mg/mL (203.85 mM)
Smiles
COc1ccc (NC (=O) c2cccc (c2) -n2cccc2) cc1S (=O) (=O) N1CCOCC1
Molecular Formula
C22H23N3O5S
Molecular Weight
441.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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