PF-05221304
PF-05221304 (NSC-170984) is an orally bioavailable, liver-directed inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme regulating de novo lipogenesis. This small molecule is utilized in research to investigate metabolic diseases, including non-alcoholic steatohepatitis (NASH), in both cellular and animal models.
Product Specifications
CAS Number
1370448-25-1
Product Name Alternative
Clesacostat, AcetylCoACarboxylase, AcetylCoA Carboxylase, ACC, NSC170984, NSC-170984, NSC 170984, STAT5 Inhibitor III, R 6238, , PF 05221304, PF05221304, PF-05221304
Field of Research
Metabolism Research
Purity
98.31% (May vary between batches)
Solubility
DMSO:95 mg/mL (189.03 mM) ; Ethanol:5 mg/mL (9.95 mM)
Smiles
O=C1CC2 (CC3=C1N (C (C) C) N=C3) CCN (C (=O) C=4C=C (N=C (OC) C4) C5=CC=C (C (O) =O) C=C5) CC2
Molecular Formula
C28H30N4O5
Molecular Weight
502.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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