N-Acetyl-R-leucine

N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies[1][2][3][4].

Product Specifications

CAS Number

[19764-30-8]

Product Name Alternative

N-Acetyl-D-leucine

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives; Monocarboxylate Transporter

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/n-acetyl-r-leucine.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)C[C@H](C(O)=O)NC(C)=O

Molecular Formula

C8H15NO3

Molecular Weight

173.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang MZ, et al. Synthesis method of amino protecting group N-substituted chiral amino acid. CN114195684. |[2]Churchill GC, et al. Acetylation turns leucine into a drug by membrane transporter switching. Sci Rep. 2021 Aug 4;11 (1) :15812.|[3]te Vruchte D, et al. Effects of N-acetyl-leucine and its enantiomers in Niemann-Pick disease type C cells. BioRxiv, 2019: 826222.|[4]Günther L, et al. N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. PLoS One. 2015 Mar 24;10 (3) :e0120891.