Thalidomide-5-OH
Thalidomide-5-OH is a cereblon (CRBN) -binding ligand derived from thalidomide, used to construct PROTAC molecules for targeted protein degradation. This small molecule enables the study of CRBN-recruiting PROTACs in both cellular and in vivo models for probing disease-related protein functions.
Product Specifications
CAS Number
64567-60-8
Product Name Alternative
CRBN, E3 ligase-recruiting Moiety, 2- (2,6-dioxopiperidin-3-yl) -5-hydroxyisoindoline-1,3-dione, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase, inhibit, Inhibitor, PROTAC, Thalidomide, Thalidomide 5 OH, Thalidomide5OH, Thalidomide-5-OH
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
97.54% (May vary between batches)
Solubility
DMSO:60 mg/mL (218.79 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.29 mM)
Smiles
O=C1N (C (=O) C=2C1=CC (O) =CC2) C3C (=O) NC (=O) CC3
Molecular Formula
C13H10N2O5
Molecular Weight
274.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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