Crizotinib hydrochloride
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a potent small molecule inhibitor targeting anaplastic lymphoma kinase (ALK) and c-Met with IC50 values of 20 nM and 8 nM, respectively. It is widely used in preclinical research for investigating non-small cell lung cancer and other malignancies, demonstrating efficacy in both cellular assays and animal models.
Product Specifications
CAS Number
1415560-69-8
Product Name Alternative
PF02341066, PF-02341066 hydrochloride, PF-02341066, PF02341066 Hydrochloride, PF-02341066 Hydrochloride, PF 02341066, PF 02341066 Hydrochloride, ROS, ROSKinase, ROS Kinase, inhibit, Inhibitor, HGFR, Crizotinib, Crizotinib Hydrochloride, Crizotinib hydrochloride, c-Met, cMet/HGFR, cMet, c-Met/HGFR, CD246, Cluster of differentiation 246, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), Autophagy, ALK tyrosine kinase receptor, ALK
Field of Research
Cardiovascular Research, Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.73% (May vary between batches)
Solubility
DMSO:10 mg/mL (20.54 mM) ; H2O:50 mg/mL (102.71 mM)
Smiles
Cl.C[C@@H] (Oc1cc (cnc1N) -c1cnn (c1) C1CCNCC1) c1c (Cl) ccc (F) c1Cl
Molecular Formula
C21H23Cl3FN5O
Molecular Weight
486.8
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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