JCN037
JCN037 is a potent, brain-penetrant, non-covalent inhibitor of EGFR, demonstrating high potency against wild-type, phosphorylated wild-type, and phosphorylated EGFRvIII with IC50 values in the low nanomolar range. This profile supports its application in preclinical research for investigating EGFR-driven pathologies, including glioblastoma, in both cellular and animal models.
Product Specifications
CAS Number
2305154-31-6
Product Name Alternative
EGFR, ErbB-1, Epidermal growth factor receptor, HER1, JCN 037, JCN037, JCN-037, JGK 037, JGK037, JGK-037, inhibit, Inhibitor
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.50% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:1 mg/mL (2.66 mM) ; DMSO:10 mg/mL (26.58 mM)
Smiles
Fc1c (Br) cccc1Nc1ncnc2cc3OCCOc3cc12
Molecular Formula
C16H11BrFN3O2
Molecular Weight
376.18
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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