SKI V
SKI V is a potent, non-lipid inhibitor of sphingosine kinase (SPHK; IC50 = 2 μM) and PI3K (IC50 = 6 μM) . This dual activity induces apoptosis and confers antitumor properties, making it a valuable tool for studying cancer signaling pathways in both cellular and animal models.
Product Specifications
CAS Number
24418-86-8
Product Name Alternative
Second, Phosphoinositide 3-kinase, PI3K, SKI V, S1PReceptor, S1P, S1P Receptor, sphingosine, Sphingosine kinase, SphK, Inhibitor, inhibit, noncompetitive, non-lipid, kinase, mitogenic, messenger, GST-hSK, Apoptosis, antitumor
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.78% (May vary between batches)
Solubility
DMSO:2.55 mg/mL (10.03 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.93 mM)
Smiles
Oc1ccc (\C=C2\Oc3ccccc3C2=O) cc1O
Molecular Formula
C15H10O4
Molecular Weight
254.24
Storage Conditions
-20°C
Notes
For research use only.
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