Dabrafenib Mesylate
Dabrafenib Mesylate is a potent and selective B-Raf inhibitor, with IC50 values of 0.6 nM for RafV600E and 5.0 nM for c-Raf. It is widely used in preclinical research to investigate targeted therapies for BRAF-mutant cancers in both cellular assays and animal models.
Product Specifications
CAS Number
1195768-06-9
Product Name Alternative
Raf kinases, Raf, Dabrafenib, Dabrafenib Mesylate, GSK 2118436, GSK 2118436 Mesylate, GSK 2118436B, GSK2118436, GSK-2118436, GSK2118436 Mesylate, GSK-2118436 Mesylate, Inhibitor, inhibit
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.45% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.36 mM) ; DMSO:85 mg/mL (138.06 mM)
Smiles
CS (O) (=O) =O.CC (C) (C) c1nc (c (s1) -c1ccnc (N) n1) -c1cccc (NS (=O) (=O) c2c (F) cccc2F) c1F
Molecular Formula
C24H24F3N5O5S3
Molecular Weight
615.67
Storage Conditions
-20°C
Notes
For research use only.
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