IQ-3
IQ3 is a potent and selective JNK3 inhibitor (Kd = 66 nM) with additional activity against JNK1 and JNK2. It suppresses NF-κB/AP1-driven transcription (IC50 = 1.4 μM) and reduces pro-inflammatory cytokine production, such as TNF-α and IL-6, in cellular assays. This profile makes it a valuable research tool for studying JNK signaling in neuroinflammation and other disease models.
Product Specifications
CAS Number
312538-03-7
Product Name Alternative
TNF-α, IQ 3, IQ3, IQ-3, IL-6, IL-1α, IL-1β, JNK2, JNK3, JNK1, JNK, Inhibitor, inhibit
Field of Research
Signal Transduction
Purity
≥98% (May vary between batches)
Solubility
DMSO:3.42 mg/mL (10.02 mM)
Smiles
O=C (ON=C1c2ccccc2-c2nc3ccccc3nc12) c1ccco1
Molecular Formula
C20H11N3O3
Molecular Weight
341.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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