SC-43
SC-43 is an orally bioavailable small molecule agonist of SHP-1 (PTPN6) . Its mechanism involves inhibiting STAT3 phosphorylation, leading to pro-apoptotic effects demonstrated in vitro and in vivo. This activity underpins its research utility in oncology and fibrotic disease studies.
Product Specifications
CAS Number
1400989-25-4
Product Name Alternative
Anti-fibrotic, Apoptosis, apoptosis, anticancer, antiproliferative, caspase-3, PARP, orally, inhibit, Inhibitor, Phosphatase, SHP-1, p-STAT3, PTPN6, SC 43, SC43, SC-43, STAT, STAT3
Field of Research
Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
DMSO:100 mg/mL (231.59 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (7.64 mM)
Smiles
FC (F) (F) c1cc (NC (=O) Nc2cccc (Oc3ccc (cc3) C#N) c2) ccc1Cl
Molecular Formula
C21H13ClF3N3O2
Molecular Weight
431.8
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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