VAL-083
VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
Product Specifications
CAS Number
[23261-20-3]
Product Name Alternative
Dianhydrodulcitol; Dianhydrogalactitol
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/val-083.html
Purity
98.0
Solubility
H2O : 70 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H](O)[C@]1(OC1)[H])[C@@]2([H])CO2
Molecular Formula
C6H10O4
Molecular Weight
146.14
References & Citations
[1]Kaiji Hu, et al. Abstract 811: VAL083, a novel N7 alkylating agent, surpasses NSC 362856 activity and inhibits cancer stem cells providing a new potential treatment option for glioblastoma multiforme. Cancer Research. 2012 Mar 31-Apr 4.|[2]Jiang X, et al. Dianhydrogalactitol, a potential multitarget agent, inhibits glioblastoma migration, invasion, and angiogenesis. Biomed Pharmacother. 2017 Jul;91:1065-1074.|[3]Peng C, et al. 1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase. Acta Pharmacol Sin. 2017 Apr;38 (4) :561-570.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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