VAL-083
Product Specifications
UNSPSC Description
VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
Target Antigen
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/val-083.html
Solubility
DMF : ≥ 100 mg/mL|DMSO : 200 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 50 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H](O)[C@]1(OC1)[H])[C@@]2([H])CO2
Molecular Weight
146.14
References & Citations
[1]Kaiji Hu, et al. Abstract 811: VAL083, a novel N7 alkylating agent, surpasses NSC 362856 activity and inhibits cancer stem cells providing a new potential treatment option for glioblastoma multiforme. Cancer Research. 2012 Mar 31-Apr 4.|[2]Jiang X, et al. Dianhydrogalactitol, a potential multitarget agent, inhibits glioblastoma migration, invasion, and angiogenesis. Biomed Pharmacother. 2017 Jul;91:1065-1074.|[3]Peng C, et al. 1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase. Acta Pharmacol Sin. 2017 Apr;38(4):561-570.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16513/VAL-083-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16513/VAL-083-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
23261-20-3
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
EKC1741 1 Kit, containing one 96 Well Plate and all necessary reagents
MAP2K6 Colorimetric Cell-Based ELISA
Ask
View Details 
