GMB-475
GMB-475 is a PROTAC-based degrader that recruits the VHL E3 ligase to ubiquitinate and eliminate the BCR-ABL1 oncoprotein, overcoming kinase inhibitor resistance. It is a research tool for investigating targeted protein degradation in models of chronic myeloid leukemia (CML), both in cellular and preclinical in vivo studies.
Product Specifications
CAS Number
2490599-18-1
Product Name Alternative
PROTACs, GMB 475, GMB475, GMB-475, Inhibitor, inhibit, Apoptosis, Bcr-Abl1, Bcr-Abl, BcrAbl
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.78% (May vary between batches)
Solubility
DMSO:245 mg/mL (284.25 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.8 mM)
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) COCCOc2ccc (cc2) -c2cc (Nc3ccc (OC (F) (F) F) cc3) ncn2) C (C) (C) C) cc1
Molecular Formula
C43H46F3N7O7S
Molecular Weight
861.93
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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