Danicopan
Danicopan (ACH-4471) is a potent and selective oral inhibitor of factor D, binding with high affinity (Kd=0.54 nM) to block the alternative complement pathway. Its application in research includes investigating complement-mediated diseases such as PNH and aHUS, with studies conducted in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1903768-17-1
Product Name Alternative
Inhibit, Inhibitor, factor D, Danicopan, ComplementSystem, Complement System, ACH4471, ACH-4471, ACH 4471
Field of Research
Immunology & Inflammation
Purity
99.88% (May vary between batches)
Solubility
DMSO:260 mg/mL (447.96 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.61 mM)
Smiles
CC (=O) c1nn (CC (=O) N2C[C@H] (F) C[C@H]2C (=O) Nc2cccc (Br) n2) c2ccc (cc12) -c1cnc (C) nc1
Molecular Formula
C26H23BrFN7O3
Molecular Weight
580.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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