CPI-1205
CPI-1205 is a potent and selective small molecule inhibitor of EZH2, demonstrating sub-nanomolar enzymatic inhibition (IC50: 0.002 μM) and low nanomolar cellular activity (EC50: 0.032 μM) . It is a valuable chemical probe for investigating the role of EZH2 and PRC2-mediated H3K27me3 in oncology and epigenetics research, both in vitro and in vivo.
Product Specifications
CAS Number
1621862-70-1
Product Name Alternative
CPI1205, CPI-1205, CPI 1205, Lirametostat, HistoneMethyltransferase, Histone Methyltransferase, EZH2
Field of Research
Epigenetics & Chromatin
Purity
98.71% (May vary between batches)
Solubility
DMSO:95 mg/mL (183.2 mM)
Smiles
[C@H] (C) (N1C=2C (C (C (NCC3=C (OC) C=C (C) NC3=O) =O) =C1C) =CC=CC2) C4CCN (CC (F) (F) F) CC4
Molecular Formula
C27H33F3N4O3
Molecular Weight
518.57
Storage Conditions
-20°C
Notes
For research use only.
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