GAK inhibitor 49
GAK inhibitor 49 is a potent and selective ATP-competitive inhibitor of cyclin G-associated kinase (GAK), exhibiting an IC50 of 56 nM and a Ki of 0.54 nM. This compound is a valuable chemical probe for investigating GAK's roles in viral entry, autophagy, and Parkinson's disease pathology in both cellular and animal models.
Product Specifications
CAS Number
319492-82-5
Product Name Alternative
Cyclin G-associated kinase (GAK), ATP-competitive, NAK, inhibit, Inhibitor, GAK inhibitor 49, GAK inhibitor49, GAK inhibitor-49, family, selective, Serine kinase, threonin kinase, Serinekinase, threoninkinase
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Purity
98.71% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.4 mM) ; DMSO:12 mg/mL (32.4 mM)
Smiles
COc1cc (Nc2ccnc3cc (OC) c (OC) cc23) cc (OC) c1OC
Molecular Formula
C20H22N2O5
Molecular Weight
370.4
Storage Conditions
-20°C
Notes
For research use only.
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