Cyproheptadine (hydrochloride)

Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders[1][2].

Product Specifications

CAS Number

[969-33-5]

Product Name Alternative

Cyproheptadine HCl

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335, H361

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Cyproheptadine-hydrochloride.html

Concentration

10mM

Purity

99.31

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

CN1CC/C(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C/24.Cl

Molecular Formula

C21H22ClN

Molecular Weight

323.86

Precautions

H301, H315, H319, H335, H361

References & Citations

[1]Calka O, et, al. Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22 (5) : p. 424-8.|[2]Olivia A Lin, et al. The Antidepressant 5-HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function. PLoS One. 2014; 9 (1) : e87026.