Beta-Hydroxyisovalerylshikonin
Beta-Hydroxyisovalerylshikonin is a protein-tyrosine kinase inhibitor targeting enzymes like v-Src and EGFR, leading to apoptosis in tumor cells. It demonstrates cytotoxic activity in vitro, such as in HCT116 colon cancer cells with an IC50 of 30.9 μg/mL, supporting its investigation in cancer research.
Product Specifications
CAS Number
7415-78-3
Product Name Alternative
PGE, Src, PTK, Prostaglandin Receptor, ProstaglandinReceptor, β-Hydroxyisovalerylshikonin, Tyrosine Kinases, TyrosineKinases, b-Hydroxyisovalerylshikonin, AMPK, BetaHydroxyisovalerylshikonin, Beta-Hydroxyisovalerylshikonin, Beta Hydroxyisovalerylshikonin, HER1, Epidermal growth factor receptor, EGFR, ErbB-1, Fatty Acid Synthase, Fatty Acid Synthase (FASN), FattyAcidSynthase, inhibit, Inhibitor
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.16% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM) ; DMSO:10 mg/mL (25.75 mM)
Smiles
CC (C) =CC[C@@H] (OC (=O) CC (C) (C) O) C1=CC (=O) c2c (O) ccc (O) c2C1=O
Molecular Formula
C21H24O7
Molecular Weight
388.41
Storage Conditions
Keep away from moisture, keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
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