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Kynurenic acid

Product Specifications

UNSPSC Description

Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.

Target Antigen

Apoptosis; CXCR; Endogenous Metabolite; GPR35 ; iGluR

Type

Natural Products

Related Pathways

Apoptosis;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Kynurenic_acid.html

Purity

99.58

Solubility

0.1 M NaOH : 12.5 mg/mL (ultrasonic;adjust pH to 9 with NaOH)|DMSO : 9 mg/mL (ultrasonic;warming)|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(C1=NC2=CC=CC=C2C(O)=C1)O

Molecular Weight

189.17

References & Citations

[1]Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8.|[2]Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32.|[3]Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100806/Kynurenic-acid-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100806/Kynurenic-acid-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

492-27-3

Available Sizes

Curated Selection

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