AS1134900
AS1134900 is a highly selective uncompetitive allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1) with an IC50 of 0.73 μM. AS1134900 can be used in the study of cancer[1].
Product Specifications
CAS Number
[149760-98-5]
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/as1134900.html
Concentration
10mM
Purity
98.87
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCC1=NC2=C(C)C=CN(CC3=CC=C4N=C(C5=CC=CC=C5C6=NN=NN6)SC4=C3)C2=N1
Molecular Formula
C25H22N8S
Molecular Weight
466.56
References & Citations
[1]Yoshida T, et al. Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP+-Dependent Malic Enzyme 1. Biochemistry. 2022 Jul 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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