PYRIB-SO 2

PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyrib-so-2.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(OS(=O)(C2=CC=C(C=C2)N3CCNC3=O)=O)=CN=C1

Molecular Formula

C14H12ClN3O4S

Molecular Weight

353.78

References & Citations

[1]Ouellette V, et al. Modification of the phenyl ring B of phenyl 4- (2-oxoimidazolidin-1-yl) benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site. Bioorg Med Chem Lett. 2024 Jun 1;105:129745.