NCGC 607

NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase) . NCGC 607 can increase GCase activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease[1].

Product Specifications

CAS Number

[1462267-07-7]

UNSPSC

12352005

Target

Glycosidase; α-synuclein

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ncgc-607.html

Purity

99.53

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(NCC(N(C)C1=CC=CC=C1)=O)C2=CC=CC=C2OCC(NC3=CC=C(I)C=C3)=O

Molecular Formula

C24H22IN3O4

Molecular Weight

543.35

References & Citations

[1]Aflaki E, et al. A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. J Neurosci. 2016 Jul 13;36 (28) :7441-52.