Thalidomide 5-fluoride
Thalidomide 5-fluoride is a cereblon-binding ligand used to synthesize PROTAC IRAK4 degrader-1, a bifunctional molecule that targets the IRAK4 protein for degradation. This compound is a key component for developing proteolysis-targeting chimeras (PROTACs) applied in biochemical and cellular research to study IRAK4's role in oncology and immunology.
Product Specifications
CAS Number
835616-61-0
Product Name Alternative
E3 ligase-recruiting Moiety, Inhibitor, H-Isoindole-1,3 (2H) -dione, 2- (2,6-dioxo-3-piperidinyl) -5-fluoro-, Ligand for E3 Ligase, Ligands for E3 Ligase, LigandforE3Ligase, inhibit, IRAK4 protein, protac, Thalidomide 5 fluoride, Thalidomide 5fluoride, Thalidomide 5-fluoride, Thalidomide
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.62% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.95 mM) ; DMSO:80 mg/mL (289.62 mM)
Smiles
O=C1N (C (=O) C=2C1=CC (F) =CC2) C3C (=O) NC (=O) CC3
Molecular Formula
C13H9FN2O4
Molecular Weight
276.22
Storage Conditions
-20°C
Notes
For research use only.
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