Thalidomide 5-fluoride
Thalidomide 5-fluoride is a cereblon-binding ligand used to synthesize PROTAC IRAK4 degrader-1, a bifunctional molecule that targets the IRAK4 protein for degradation. This compound is a key component for developing proteolysis-targeting chimeras (PROTACs) applied in biochemical and cellular research to study IRAK4's role in oncology and immunology.
Product Specifications
CAS Number
835616-61-0
Product Name Alternative
E3 ligase-recruiting Moiety, Inhibitor, H-Isoindole-1,3 (2H) -dione, 2- (2,6-dioxo-3-piperidinyl) -5-fluoro-, Ligand for E3 Ligase, Ligands for E3 Ligase, LigandforE3Ligase, inhibit, IRAK4 protein, protac, Thalidomide 5 fluoride, Thalidomide 5fluoride, Thalidomide 5-fluoride, Thalidomide
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.62% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.95 mM) ; DMSO:80 mg/mL (289.62 mM)
Smiles
O=C1N (C (=O) C=2C1=CC (F) =CC2) C3C (=O) NC (=O) CC3
Molecular Formula
C13H9FN2O4
Molecular Weight
276.22
Storage Conditions
-20°C
Notes
For research use only.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
1220-AAT 2 Labelings
ReadiLink™ Rapid iFluor® 350 Antibody Labeling Kit *Microscale Optimized for Labeling 50 μg Antibody Per Reaction*
Sign In for Pricing
View Details 
MBS1356772-01 0.5 mg (E-Coli)
Recombinant Mouse Protein disulfide-isomerase TMX3 (Tmx3), partial
Sign In for Pricing
View Details MBS1356772-02 0.05 mg (Baculovirus)
Recombinant Mouse Protein disulfide-isomerase TMX3 (Tmx3), partial
Sign In for Pricing
View Details MBS1356772-03 0.5 mg (Yeast)
Recombinant Mouse Protein disulfide-isomerase TMX3 (Tmx3), partial
Sign In for Pricing
View Details MBS1356772-04 0.05 mg (Mammalian-Cell)
Recombinant Mouse Protein disulfide-isomerase TMX3 (Tmx3), partial
Sign In for Pricing
View Details