LOXO-195
(6RS) -LOXO-195 (BAY 2731954) is a highly potent and selective inhibitor of the Trk family of tyrosine kinases. It is utilized in biochemical and cellular research to investigate Trk-driven oncogenesis and has demonstrated antitumor activity in preclinical in vivo models of NTRK-rearranged cancers.
Product Specifications
CAS Number
1350884-56-8
Product Name Alternative
Trk, Trk receptor, Trkreceptor, (6RS) -LOXO 195, (6RS) -LOXO195, (6RS) -LOXO-195, BAY 2731954, BAY2731954, BAY-2731954, LOXO 195, LOXO195, LOXO-195
Field of Research
Signal Transduction
Purity
97.92% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM) ; DMSO:50 mg/mL (131.43 mM)
Smiles
FC=1C=C2[C@@]3 (N (C4=NC=5N (C=C4) N=CC5C (=O) NC (C) CCC2=NC1) CCC3) [H]
Molecular Formula
C20H21FN6O
Molecular Weight
380.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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