Niraparib tosylate monohyrate
Niraparib (MK-4827) is a potent PARP inhibitor that disrupts the base-excision DNA repair pathway, leading to genomic instability and apoptosis in cancer cells. It is widely used in oncology research, particularly for studying BRCA-mutant cancers, and has demonstrated efficacy in both in vitro assays and in vivo tumor models.
Product Specifications
CAS Number
1613220-15-7
Product Name Alternative
Inhibitor, inhibit, MK-4827 tosylate, Niraparib tosylate, Niraparib tosylate monohyrate, orally, lung, PARP, DNA, damage, breast, anti-tumor, Apoptosis, cancer, bioavailable, poly ADP ribose polymerase, ovarian
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Purity
97.70% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.92 mM) ; H2O:1 mg/mL (1.96 mM) ; DMSO:247.5 mg/mL (484.71 mM)
Smiles
CC1=CC=C (S (=O) (O) =O) C=C1.O=C (N) C (C2=N3) =CC=CC2=CN3C (C=C4) =CC=C4[C@@H]5CCCNC5.O
Molecular Formula
C26H30N4O5S
Molecular Weight
510.61
Storage Conditions
-20°C
Notes
For research use only.
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