MRT-81
MRT-81 is a potent smoothened (SMO) receptor antagonist effective in both human and rodent systems, inhibiting Hedgehog signaling with an IC50 of 41 nM in Shh-Light2 cells. This compound is a valuable research tool for studying the Hedgehog pathway's role in cancer, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1263132-08-6
Product Name Alternative
Shh-light2 cells, rat granule cell precursors, Smoothened, smoothened, Smo, rodent, BODIPY-cyclopamine, C3H10T1/2 cells, human, Hedgehog, Inhibitor, MRT81, MRT 81, MRT-81, inhibit
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
98.31% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:2.5 mg/mL (4.5 mM) ; DMSO:50 mg/mL (89.99 mM)
Smiles
COc1cc (cc (OC) c1OC) C (=O) NC (=S) Nc1ccc (C) c (NC (=O) c2ccc (cc2) -c2ccccc2) c1
Molecular Formula
C31H29N3O5S
Molecular Weight
555.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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