IRE1α kinase-IN-1
IRE1α kinase-IN-1 is a potent and selective inhibitor of IRE1α (ERN1), with an IC50 of 77 nM for kinase and 80 nM for RNase activity, showing 100-fold selectivity over IRE1β. It blocks ER stress-induced oligomerization and autophosphorylation, making it a valuable tool for studying the unfolded protein response in cellular and animal models of disease.
Product Specifications
CAS Number
2328097-41-0
Product Name Alternative
Autophosphorylation, cells, endoplasmic, endoribonuclease, Inhibitor, Inositol requiring enzyme 1, HEK293, oligomerization, IRE1α kinaseIN1, IRE-1α kinase-IN-1, IRE1α kinase-IN-1, IRE1α kinase IN 1, IRE1α, IRE1a kinase-IN-1, IRE1alpha kinase-IN-1, IRE1, inhibit, reticulum, selectivity
Field of Research
Cell Biology, Signal Transduction
Purity
99.18% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.98 mM) ; DMSO:10 mg/mL (19.8 mM)
Smiles
CN1CCC (CNc2cc (Cl) nn3c (cnc23) -c2cc3nc (Nc4ccccc4) [nH]c3cc2F) CC1
Molecular Formula
C26H26ClFN8
Molecular Weight
504.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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