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GSK3685032

GSK3685032 is a potent, selective, and reversible non-covalent inhibitor of DNMT1 (IC50 = 36 nM) . It induces DNA demethylation and gene reactivation, demonstrating robust anti-proliferative effects in cancer cell lines and in vivo tumor models, making it a valuable tool for epigenetic and oncology research.

Product Specifications

CAS Number

2170137-61-6

Product Name Alternative

Cancer, DNA Methyltransferase, DNA MTases, DNAMethyltransferase, DNMT1, DNMTs, GSK3685032, GSK-3685032, GSK 3685032, leukemia, GDM-1, lymphoma, Inhibitor, inhibit, multiple myeloma, MV4–11

Field of Research

Epigenetics & Chromatin

Purity

98.56% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.76 mM) ; DMSO:26.4 mg/mL (62.78 mM)

Smiles

CCc1c (C#N) c (SC (C (N) =O) c2ccccc2) nc (N2CCC (N) CC2) c1C#N

Molecular Formula

C22H24N6OS

Molecular Weight

420.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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