RORγt inverse agonist 13
Compound 3i is a potent and selective RORγt inverse agonist with an IC50 of 63.8 nM, demonstrating oral activity and favorable drug-like properties. It is a valuable research tool for investigating Th17 cell biology and autoimmune diseases in both cellular and animal models.
Product Specifications
CAS Number
2170477-75-3
Product Name Alternative
Inhibit, Inhibitor, ROR, RORγt inverse agonist13, RORγt inverse agonist-13, RORγt, RORγt inverse agonist 13, RORgammat inverse agonist 13, RORrt inverse agonist 13, RAR-related orphan receptor
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.00% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:1 mg/mL (1.95 mM) ; DMSO:10 mg/mL (19.48 mM)
Smiles
OC (=O) Cc1ccc (CNC (=O) Nc2cc (Cl) c (c (Cl) c2) -c2ccccc2OC (F) (F) F) cc1
Molecular Formula
C23H17Cl2F3N2O4
Molecular Weight
513.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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