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RORγt inverse agonist 13

Compound 3i is a potent and selective RORγt inverse agonist with an IC50 of 63.8 nM, demonstrating oral activity and favorable drug-like properties. It is a valuable research tool for investigating Th17 cell biology and autoimmune diseases in both cellular and animal models.

Product Specifications

CAS Number

2170477-75-3

Product Name Alternative

Inhibit, Inhibitor, ROR, RORγt inverse agonist13, RORγt inverse agonist-13, RORγt, RORγt inverse agonist 13, RORgammat inverse agonist 13, RORrt inverse agonist 13, RAR-related orphan receptor

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Purity

99.00% (May vary between batches)

Solubility

10% DMSO+90% Corn Oil:1 mg/mL (1.95 mM) ; DMSO:10 mg/mL (19.48 mM)

Smiles

OC (=O) Cc1ccc (CNC (=O) Nc2cc (Cl) c (c (Cl) c2) -c2ccccc2OC (F) (F) F) cc1

Molecular Formula

C23H17Cl2F3N2O4

Molecular Weight

513.29

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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