PHD-1-IN-1
PHD-1-IN-1 is a highly potent and selective inhibitor of the HIF prolyl hydroxylase domain 1 (PHD1) enzyme, demonstrating an IC50 of 34 nM. This compound is a valuable chemical tool for investigating hypoxia signaling pathways and has been utilized in both cellular and animal models to study ischemic and inflammatory conditions.
Product Specifications
CAS Number
2009343-14-8
Product Name Alternative
Active, Arg367-out, Inhibitor, HIF, HIF ProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIFProlylHydroxylase, HIF-PH, HIFs, Hypoxia-inducible factors, Fe2+, inhibit, ion, iron, pocket, orally, PHD 1 IN 1, PHD1, PHD-1, PHD1IN1, PHD-1-IN-1, site
Field of Research
Epigenetics & Chromatin, Metabolism Research
Purity
99.74% (May vary between batches)
Solubility
DMSO:11 mg/mL (49.95 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (36.33 mM)
Smiles
N#Cc1ccc (cc1) -c1cccc2ncnn12
Molecular Formula
C13H8N4
Molecular Weight
220.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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