CU-115
CU-115 is a potent and selective TLR8 antagonist (IC50 = 1.04 μM) that shows minimal activity against TLR7 (>50 μM) . It effectively inhibits R-848-induced TNF-α and IL-1β production in THP-1 cells, making it a valuable tool for studying TLR8-mediated signaling in autoimmune and inflammatory disease research.
Product Specifications
CAS Number
2471982-20-2
Product Name Alternative
TLR8, N- (4- (3,5-bis (trifluoromethyl) phenoxy) phenyl) -2-fluoro-6-iodobenzamide, CU115, CU-115, CU 115
Field of Research
Immunology & Inflammation
Purity
99.96% (May vary between batches)
Solubility
DMSO:45 mg/mL (79.06 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (3.51 mM)
Smiles
Fc1cccc (I) c1C (=O) Nc1ccc (Oc2cc (cc (c2) C (F) (F) F) C (F) (F) F) cc1
Molecular Formula
C21H11F7INO2
Molecular Weight
569.21
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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