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CU-115

CU-115 is a potent and selective TLR8 antagonist (IC50 = 1.04 μM) that shows minimal activity against TLR7 (>50 μM) . It effectively inhibits R-848-induced TNF-α and IL-1β production in THP-1 cells, making it a valuable tool for studying TLR8-mediated signaling in autoimmune and inflammatory disease research.

Product Specifications

CAS Number

2471982-20-2

Product Name Alternative

TLR8, N- (4- (3,5-bis (trifluoromethyl) phenoxy) phenyl) -2-fluoro-6-iodobenzamide, CU115, CU-115, CU 115

Field of Research

Immunology & Inflammation

Purity

99.96% (May vary between batches)

Solubility

DMSO:45 mg/mL (79.06 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (3.51 mM)

Smiles

Fc1cccc (I) c1C (=O) Nc1ccc (Oc2cc (cc (c2) C (F) (F) F) C (F) (F) F) cc1

Molecular Formula

C21H11F7INO2

Molecular Weight

569.21

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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