Angoline
Angoline hydrochloride is a potent and selective small molecule inhibitor of the IL-6/STAT3 signaling pathway (IC50: 11.56 μM) . It suppresses STAT3 phosphorylation and downstream gene expression, demonstrating anti-proliferative effects in cancer cell studies, making it a valuable research tool for oncology and immunology.
Product Specifications
CAS Number
21080-31-9
Product Name Alternative
IL Receptor, Inhibitor, ILReceptor, IL-6, inhibit, 6-Methoxyldihydrochelerythrine, Angoline, anticancer, proliferation, STAT3, STAT, phosphorylation
Field of Research
Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.90% (May vary between batches)
Solubility
DMSO:9.06 mg/mL (23.88 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM)
Smiles
COC1N (C) c2c (ccc3cc4OCOc4cc23) -c2ccc (OC) c (OC) c12
Molecular Formula
C22H21NO5
Molecular Weight
379.41
Storage Conditions
Keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
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