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Cucurbitacin I

Cucurbitacin I (JSI-124) is a natural product that selectively inhibits the JAK2/STAT3 signaling pathway. It has demonstrated anti-cancer activity in both in vitro cell-based assays and in vivo animal models, making it a valuable research tool for oncology and signal transduction studies.

Product Specifications

CAS Number

2222-07-3

Product Name Alternative

Cucurbitacin I, Elatericin B, inhibit, JSI 124, JSI124, JSI-124, Inhibitor, NSC 521777, Janus kinase, JAK, JAK2, NSC521777, NSC-521777, STAT, STAT3

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

96.69% (May vary between batches)

Solubility

DMSO:95 mg/mL (184.59 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.86 mM)

Smiles

[H][C@@]12CC=C3[C@@] ([H]) (C=C (O) C (=O) C3 (C) C) [C@]1 (C) C (=O) C[C@]1 (C) [C@H] ([C@H] (O) C[C@@]21C) [C@@] (C) (O) C (=O) \C=C\C (C) (C) O

Molecular Formula

C30H42O7

Molecular Weight

514.65

Storage Conditions

Store at low temperature, keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Notes

For research use only.

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