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Olafertinib

Olafertinib (RX-518) is an oral, irreversible, and mutant-selective EGFR inhibitor designed to target T790M-mediated resistance in non-small cell lung cancer (NSCLC) . It demonstrates potent activity in both cellular assays and in vivo xenograft models, supporting its investigation as a therapeutic agent for EGFR-mutant NSCLC.

Product Specifications

CAS Number

1660963-42-7

Product Name Alternative

CK 101, CK101, CK-101, EGFR, EGFR (T790M), EGFR-IN-3, Epidermal growth factor receptor, ErbB-1, HER1, Inhibitor, Olafertinib, NSCLC, inhibit, RX 518, RX518, RX-518

Field of Research

Cardiovascular Research, Signal Transduction

Purity

98.43% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.54 mM) ; DMSO:120 mg/mL (226.17 mM) ; H2O:Insoluble

Smiles

OCCN1CCN (CC1) c1ccc (Nc2ncc3cccc (-c4cccc (NC (=O) C=C) c4) c3n2) c (F) c1F

Molecular Formula

C29H28F2N6O2

Molecular Weight

530.57

Storage Conditions

Store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Notes

For research use only.

Available Sizes

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