Pralsetinib
Pralsetinib (BLU-667) is a potent and selective RET kinase inhibitor effective against wild-type RET, multiple mutants (V804L, V804M, M918T), and the CCDC6-RET fusion. It is a valuable research tool for investigating RET-driven pathologies, with demonstrated activity in both cellular assays and in vivo models of RET-altered cancers.
Product Specifications
CAS Number
2097132-94-8
Product Name Alternative
Inhibitor, inhibit, cRET, Blu667, BLU-667, BLU 667, Pralsetinib, RET
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.88% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.18 mM) ; DMSO:126.25 mg/mL (236.6 mM)
Smiles
CO[C@]1 (CC[C@@H] (CC1) c1nc (C) cc (Nc2cc (C) [nH]n2) n1) C (=O) N[C@@H] (C) c1ccc (nc1) -n1cc (F) cn1
Molecular Formula
C27H32FN9O2
Molecular Weight
533.6
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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