Thapsigargin
Thapsigargin is a natural SERCA inhibitor that disrupts calcium homeostasis by blocking Ca2+ uptake into the ER/SR, leading to elevated cytosolic Ca2+ and ER stress. It is widely used in vitro and in vivo to study apoptosis, autophagy, and ER stress signaling pathways in cancer and neurodegenerative disease research.
Product Specifications
CAS Number
67526-95-8
Product Name Alternative
Unfolded, protein , response, SARSCoV, SARS coronavirus, SARS-CoV, stress, Thapsigargin, inhibit, Inhibitor, Apoptosis, CalciumChannel, Ca2+ channels, Ca2+-ATPase, Calcium Channel, Ca channels, coronavirus
Field of Research
Cell Biology
Purity
>98%
Bioactivity
SERCA inhibitor
Form
Wax
Solubility
Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml) .
Smiles
O (C (CCCCCCC) =O) [C@H]1[C@]2 (C ([C@]3 ([C@] (O) ([C@@H] (OC (CCC) =O) C[C@@]2 (OC (C) =O) C) [C@] (C) (O) C (=O) O3) [H]) =C (C) [C@@H]1OC (/C (=C\C) /C) =O) [H]
Molecular Formula
C34H50O12
Molecular Weight
650.77
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
Isolated from Thapsia garganica
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