Filanesib
Filanesib (ARRY-520) is a potent and selective kinesin spindle protein (KSP/Eg5) inhibitor with an IC50 of 6 nM, demonstrating anti-proliferative activity. It is widely used in cancer research, particularly in studying mitosis, and has shown efficacy in both in vitro cellular assays and in vivo xenograft models of various malignancies.
Product Specifications
CAS Number
885060-09-3
Product Name Alternative
ARRY 520, ARRY520, ARRY-520, Filanesib, KSP
Field of Research
Cell Biology, Signal Transduction
Purity
98.06% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.85 mM) ; DMSO:90 mg/mL (214.04 mM)
Smiles
CON (C) C (=O) N1N=C (S[C@@]1 (CCCN) c1ccccc1) c1cc (F) ccc1F
Molecular Formula
C20H22F2N4O2S
Molecular Weight
420.48
Storage Conditions
Store at low temperature, keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
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