Gedatolisib
A highly potent, selective, dual PI3K/mTOR inhibitor with IC50 of 0.4/6/8/6/1.6 nM for PI3Kα/β/γ/δ/mTOR, respectively; also potently inhibits PI3Kα mutant H1047R and E545K with IC50 of 0.6 and 0.6 nM; prevents the pAkt at Thr 308 with IC50 of 8 nM, and suppresses pAkt S473 with IC50 of <10 nM in cells; demonstrates antitumor efficacy in both subcutaneous and orthotopic xenograft tumor models.Blood Cancer Phase 3 Clinical.
Product Specifications
CAS Number
1197160-78-3
Product Name Alternative
PF-05212384 | PKI-587
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=C (C2=NC (N3CCOCC3) =NC (N4CCOCC4) =N2) C=C1) NC5=CC=C (C (N6CCC (N (C) C) CC6) =O) C=C5
Molecular Formula
C32H41N9O4
Molecular Weight
615.72
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4-{[4- (Dimethylamino) -1-piperidinyl]carbonyl}phenyl) -3-{4-[4,6-di (4-morpholinyl) -1,3,5-triazin-2-yl]phenyl}urea
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