Brigatinib
Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib; shows high activity against both sensitive and resistant H3122 cells, decreasing cell growth, suppressing ALK phosphorylation, and inducing apoptosis; AP26113 is also active in Ba/F3 cells expressing either native or mutant EML4-ALK with IC50 of 10 and 24 nM, respectively; demonstrates promising activity in crizotinib resistant.Lung Cancer Approved.
Product Specifications
CAS Number
1197953-54-0
Product Name Alternative
AP-26113 | AP26113
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in Ethanol
Smiles
CN1CCN (CC1) C2CCN (CC2) C3=CC (=C (C=C3) NC4=NC=C (C (=N4) NC5=CC=CC=C5P (=O) (C) C) Cl) OC
Molecular Formula
C29H39ClN7O2P
Molecular Weight
584.0924
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Pyrimidinediamine, 5-chloro-N4-[2- (dimethylphosphinyl) phenyl]-N2-[2-methoxy-4-[4- (4-methyl-1-piperazinyl) -1-piperidinyl]phenyl]-
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