Mirin
A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity; prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity; inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity; inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
Product Specifications
CAS Number
1198097-97-0
Product Name Alternative
Mirin
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
O=C1NC (S/C1=C\C2=CC=C (O) C=C2) =N
Molecular Formula
C10H8N2O2S
Molecular Weight
220.2477
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4 (5H) -Thiazolone, 2-amino-5-[ (4-hydroxyphenyl) methylene]-, (5Z) -
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