Duvelisib
A potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM; displays high selectivity for PI3K δ/γ than other protein kinases; exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation; exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.Blood Cancer Phase 3 Clinical.
Product Specifications
CAS Number
1201438-56-3
Product Name Alternative
IPI-145 | INK-1197
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 41 mg/mL
Smiles
O=C1N (C2=CC=CC=C2) C ([C@@H] (NC3=C4N=CNC4=NC=N3) C) =CC5=C1C (Cl) =CC=C5
Molecular Formula
C22H17ClN6O
Molecular Weight
416.863
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1 (2H) -Isoquinolinone, 8-chloro-2-phenyl-3-[ (1S) -1- (9H-purin-6-ylamino) ethyl]-
Available Sizes
Frequently Asked Questions
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