DMH-1
DMH1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively; significantly reduces the percentage of cells expressing the pluripotency marker proteins OCT4 and Nanog in both SM3 and CA6 cells, induces regulation of pluripotency and neural precursor marker mRNAs; reduces the canonical phosphorylation of Smads 1,5 and 9, inhibits HeLa and MCF-7 cell proliferation; significantly reduces the tumor growth in human lung cancer xenograft model.
Product Specifications
CAS Number
1206711-16-1
Product Name Alternative
DMH1 | DMH 1
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
DMSO: 11.5 mg/mL
Smiles
CC (OC1=CC=C (C2=CN3C (N=C2) =C (C4=CC=NC5=CC=CC=C45) C=N3) C=C1) C
Molecular Formula
C24H20N4O
Molecular Weight
380.4418
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 4-[6-[4- (1-methylethoxy) phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-
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